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KMID : 0362420120500040285
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Journal of Korean Academy of Prosthodontics
2012 Volume.50 No. 4 p.285 ~ p.291
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A study of mesenchymal stem cell proliferation and surface characteristics of the titanium discs coated with MS275/PLGA by an electrospray
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Yoo Soo-Yeon
Kim Seong-Kyun
Heo Seong-Joo
Koak Jai-Young
Park Yoon-Kyung
Kim E-Na
Lee Joo-Hee
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Abstract
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Purpose: This study was conducted to identify the surface characteristics of titanium discs coated with MS275/PLGA by electrospray and which is effective to mesenchymal stem cell proliferation.
Materials and Methods: We used anodized surface coated with PLGA as a control group and anodized surface coated with MS275 , , as test groups. To examine that the coating particles are nanometer sized, FE-SEM was used and AFM was utilized to determine the difference of coating surface roughness. We checked the mesenchymal stem cell proliferation by using MTT assay on , , days.
Results: There was no significant difference between control groups and test groups in AFM results (P>.05). In MTT assay results, mesenchymal stem cell proliferation was increased with time, at day, cell viability on discs coated with MS275 was significantly higher than control group (P<.05). As SEM showed, the number of cells on all discs was increased and the morphology of cell attachment was also wider and closer with time.
Conclusion: Titanium surface coated with MS275/PLGA showed significantly higher cell proliferation and the more density of MS275 was dispersed on titanium discs, the faster cells grew.
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KEYWORD
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Titanium, MS275, PLGA, Mesenchymal stem cells
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